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Hur bra funkar Ibogain mot alcohol?

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eZy



Joined: 11 Feb 2007
Posts: 3
Topics: 1

PostPosted: Sun 11 Feb, 2007 20:50    Post subject: Hur bra funkar Ibogain mot alcohol? Reply with quote

Jag vill ha information om hur bra en ibogain behandling fungerar mot alcohol, är det värt resan och besväret?
Såg i en amerikansk dokumentär att det inte tar bort avtändningen/avgiftningen.
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Masque
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Joined: 14 May 2006
Posts: 468
Topics: 68

PostPosted: Sun 11 Feb, 2007 22:41    Post subject: Reply with quote

Det finns rapporter från alkoholister som har fått positiva resultat av en ibogainbehandling.

Exempelvis http://www.ibogaine.co.uk/exp1.htm

Har inte hittat någon mer vid en snabb googlesökning, men jag har för mig att några svenskar har behandlats för bl.a alkoholproblem genom ibogain.se, dom kanske kan berätta mera.

Om du undrar vad det finns för vetenskapliga bevis för att det fungerar mot alkoholism, läs: http://www.reactivereports.com/43/43_1.html

Sedan deras forskning:

Quote:
Anti-Addiction Drug Ibogaine against Alcohol Consumption

Dao-Yao He,1 * Nancy N. H. McGough,1 * Ajay Ravindranathan,1 Jerome Jeanblanc,1 Marian L. Logrip,1,3 Khanhky Phamluong,1 Patricia H. Janak,1,2,3 and Dorit Ron1,2,3

1Ernest Gallo Research Center, 2Department of Neurology, 3Neuroscience Graduate Program, University of California, San Francisco, Emeryville, California 94608

Alcohol addiction manifests as uncontrolled drinking despite negative consequences. Few medications are available to treat the disorder. Anecdotal reports suggest that ibogaine, a natural alkaloid, reverses behaviors associated with addiction including alcoholism; however, because of side effects, ibogaine is not used clinically. In this study, we first characterized the actions of ibogaine on ethanol self-administration in rodents. Ibogaine decreased ethanol intake by rats in two-bottle choice and operant self-administration paradigms. Ibogaine also reduced operant self-administration of ethanol in a relapse model. Next, we identified a molecular mechanism that mediates the desirable activities of ibogaine on ethanol intake. Microinjection of ibogaine into the ventral tegmental area (VTA), but not the substantia nigra, reduced self-administration of ethanol, and systemic administration of ibogaine increased the expression of glial cell line-derived neurotrophic factor (GDNF) in a midbrain region that includes the VTA. In dopaminergic neuron-like SHSY5Y cells, ibogaine treatment upregulated the GDNF pathway as indicated by increases in phosphorylation of the GDNF receptor, Ret, and the downstream kinase, ERK1 (extracellular signal-regulated kinase 1). Finally, the ibogaine-mediated decrease in ethanol self-administration was mimicked by intra-VTA microinjection of GDNF and was reduced by intra-VTA delivery of anti-GDNF neutralizing antibodies. Together, these results suggest that GDNF in the VTA mediates the action of ibogaine on ethanol consumption. These findings highlight the importance of GDNF as a new target for drug development for alcoholism that may mimic the effect of ibogaine against alcohol consumption but avoid the negative side effects.


http://www.jneurosci.org/cgi/content/abstract/25/3/619

och en annan forskning:

Quote:
* Rezvani AH,
* Overstreet DH,
* Lee YW.

Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine at Chapel Hill, USA.

Alcohol-preferring (P), Fawn-Hooded (FH) and alcohol-accepting (AA) rats were injected intraperitoneally (IP) or subcutaneously (SC) with different doses (10, 30, and 60 mg/kg) of Ibogaine or vehicle. In a separate experiment, FH rats were administered intragastrically (IG) with either 60 mg/kg of Ibogaine or vehicle for 5 days. In addition, the effects of Ibogaine on blood alcohol concentrations were measured. Our data show that, contrary to the SC administration of Ibogaine, IP administration of the agent significantly and dose-dependently reduced alcohol intake in these rats. Subchronic IG administration of 60 mg/kg of Ibogaine into FH rats significantly reduced alcohol intake without the development of tolerance or a significant effect on food or water intake. A single IP injection of 60 mg/kg Ibogaine into FH rats did not affect the blood alcohol levels. These results show that Ibogaine when injected IP or IG, but not SC, can significantly reduce alcohol intake without an effect on blood alcohol concentrations or food intake. These findings may suggest the involvement of Ibogaine's metabolite(s) in reducing alcohol intake. Although the neuronal mechanism(s) of action of Ibogaine on the regulation of alcohol intake is not fully understood, it is speculated that Ibogaine or its metabolite(s) exerts its attenuating effect on alcohol intake by modulating neurotransmitters/neuromodulators proposed to be involved in regulation of alcohol consumption.

PMID: 8545483 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8545483&dopt=Abstract
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Operator



Joined: 08 Jun 2006
Posts: 270
Topics: 45

PostPosted: Tue 13 Feb, 2007 09:17    Post subject: Re: Hur bra funkar Ibogain mot alcohol? Reply with quote

eZy wrote:
Jag vill ha information om hur bra en ibogain behandling fungerar mot alcohol, är det värt resan och besväret?
Såg i en amerikansk dokumentär att det inte tar bort avtändningen/avgiftningen.


Vilken dokumentär hänvisar du till, det skulle ju kunna vara bra att veta för att svara på argumenten i den, eller vad tror du?

Har ingen överdrivet bra information att ge dig om ibogainets effekter på alkoholmissbruk just nu som tillfredställande besvarar din fråga. Herr Venulejo uttrycker sig såhär


"Alcohol - of all the people that I`ve treated just 3
had alcohol problems and definitely it helped 2 of
them to lower down the cravings for alcohol. Didn`t
have any effect on the 3rd one."


Så är det värt det?

Man kan knappast dra några större slutsatser med det materialet va?
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eZy



Joined: 11 Feb 2007
Posts: 3
Topics: 1

PostPosted: Tue 13 Feb, 2007 10:14    Post subject: Reply with quote

Rubriken är:
Demitri on Ibogaine with Paul DeRienzo

ganska säker på att det är den
använd sökordet "ibogaine" så kommer den högst upp


så två av tre kunde "minska" sitt beroende?

det får mig nästan att önska att personen jag har i åtanke hade ett heroin misbruk iställett Rolling Eyes
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Masque
Administratör


Joined: 14 May 2006
Posts: 468
Topics: 68

PostPosted: Tue 13 Feb, 2007 16:45    Post subject: Reply with quote

Dimitri Mugianis heter han.

Här är avsnittet från Let Them Talk: http://www.youtube.com/watch?v=WJ3rL57pGD0

Jag kollade på det nu och jag hörde bara typ en mening som handade om alkohol, ungefär "its effective against alcohol" och sedan snabbt vidare till nikotin och benzo?
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Operator



Joined: 08 Jun 2006
Posts: 270
Topics: 45

PostPosted: Thu 15 Feb, 2007 07:56    Post subject: Re: Hur bra funkar Ibogain mot alcohol? Reply with quote

eZy wrote:
Jag vill ha information om hur bra en ibogain behandling fungerar mot alcohol, är det värt resan och besväret?
Såg i en amerikansk dokumentär att det inte tar bort avtändningen/avgiftningen.


http://www.reactivereports.com/43/43_1.html
Ibogaine Gaining on Alcohol Addiction (rats)

Verkar fungera för att minsta råttors alkoholsug ... men i dagsläget finns det mycket lite information om övrigt som jag ser det just nu. Alkohol är en skenbart O-komplex drog vars beroenden och missbruk orsaker samhället gigantiska skador. Tyvärr kan jag inte se att ibogain i dagsläget kan rekommenderas.


En annan tänkbarhet manande till försiktighet är ju att storkonsumenter av alkohol inte helt sällan också har en mycket ansträngd leverfunktion, vilket kan vara en direkt kontraindikation till ibogainbehandling. Så grundsvaret på din fråga är : vet inte, det finns anledning att avvakta tills man vet mera.
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eZy



Joined: 11 Feb 2007
Posts: 3
Topics: 1

PostPosted: Fri 16 Feb, 2007 13:48    Post subject: Reply with quote

verkar ju ha effekt men pga lever detaljen så kanske det vore ett måste att ha varit "clean" ett tag innan en behandling.

och om documentären.. var ganska säker på att det var den men kan ju ha haft fel
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