En väldigt intressant artikel jag hittade om Ibogain och en variant utav det som kallas för Noribogain. Beskrivs mycket i artikeln Dr. Deborah Marsh arbete och den forskning hon håller på med samt ger en väldigt utförlig bild av Ibogaine, den forskning som finns på området och hur den har fortskridit.
Jag fick en liten fundering efter jag läst igenom artikeln och kollade lite på huvudsidan här på Ibogain.se, det som står i artikeln som kommer från Nexus:
I Nederländerna har man sedan 1990 behandlat 40 missbrukare under kontrollerade förhållanden. USAs federala läkemedelsstyrelse Food and Drug Administration (FDA) har dock inte godkänt ibogainet för användning i landet, och drogen är i USA olaglig.
man skulle ju kunna påpeka att FDA har gett tillstånd till Ibogain-forskning i viss skala och den har under ledning av Deborah Marsh och hennes team gett väldigt goda resultat där b.l.a flera hundra missbrukare behandlats. det kan nog vara bra att påpeka så inte en betraktare får intrycket att det är helt bannlyst i USA.
Edit: såg att Nexus har en svensköversatt version från en artikel som skrevs 1995. Samma år som FDA godkände att forskningen kring Ibogaine togs upp på nytt efter att ha varit avbruten en 2-års period. Så det kan vara därför det inte står med i Nexus-artikeln
A 40-year-old Traverse City native who was intensely addicted for two years to methamphetamine says he owes his life to ibogaine, an illegal and experimental drug that has helped hundreds of people break their drug or alcohol addiction.
Aaron, not his real name, said meth nearly killed him. He lost 80 pounds, leaving him malnourished and sick. He also lost his house, his wife, and his catering business.
Aaron’s brother, desperate to get him off drugs, told him about the power of “plant teachers”-- mind-altering drugs that take you on a deeply spiritual trip, allowing a reset to your healthy psyche before life turned ugly.
For Aaron, who we reported on two weeks ago, that drug was ibogaine, a hallucinogenic. Thirty-six hours after taking it, he completely lost his craving for meth. He’s been clean for 90 days and is grateful for a second chance at living a healthy life and raising his infant daughter. He didn’t return phone calls for this article, so it isn’t clear how he’s doing now.
The science behind ibogaine is this: the drug, taken from an African plant, metabolizes in the body into noribogaine. This metabolite chemically stops a person’s addiction in its tracks. As an added bonus, the person doesn’t suffer withdrawal pains, but instead experiences a very long, light-filled trip through his life, Scrooge style. Those visions often help an addict unearth answers to his habit.
Ibogaine alone is no magic bullet. For a “honeymoon period” lasting anywhere from four weeks to 12 weeks, the person has no craving for drugs. But here’s the downside: once the noribogaine is washed out of the system, the deep craving for drugs may return.
There are no statistics for long-term success, but one thing is clear: some addicts miss their old lifestyle of gathering at a table everyday and shooting up with old friends. Drugs are the glue of these friendships and it’s hard to lose the glue. To succeed, the addict needs to attend support groups and make new, “clean” friends. Most importantly, the recovering addict has to learn how to cope with life’s emotional ups and downs without drugs and, for many, that’s very hard to do.
Many ex-addicts can overcome the craving. Others ask for a “booster” ibogaine treatment, although most are not crazy about the idea of repeating the 34-hour “trip.” For others, one treatment is enough.
So explains Dr. Deborah Mash, a neuro-scientist who has studied ibogaine for 14 years. She is an esteemed professor of neurology at the University of Miami School of Medicine. At first, this Harvard-educated scientist, her rapid speech peppered with scientific terminology, seems an odd advocate for a hallucinogenic, but she has absolute, unbridled enthusiasm.
“I was in a Washington airport last week and saw a severe alcoholic who was treated with ibogaine. She was there with her daughter and her family. She looked so good. It’s people like her that keeps me sane.
“I’m a scientist, and I’m not going to overstate these research findings. I don’t have the statistics. But what I can tell you today is that we have success stories, not one, not two, but hundreds of success stories. It’s very rare to have all this human data on an experimental drug. We know it works.”
Mash said the drug has been successfully synthesized into noribogaine, which the liver makes from ibogaine. The drug retains the anti-addiction properties of ibogaine, but loses the hallucinogenic side effects. Dr. Stanley Glick of Albany Medical College also tested a synthetic derivative called 18-MC on rats in the late 1990s with promising results. Mash, who owns the patent on noribogaine, has a dream of giving addicts a noribogaine patch, which they could wear for a lifetime, if necessary.
Mash has not publicly presented her ibogaine data, but said it shows good results for those addicted to most opiates, inconsistent results for smokers, and “stunning” outcomes for alcoholics.
“It is not as impressive for crack cocaine, but we have success here, too. Most crack addicts require a second treatment when the cravings return. This probably reflects neuro-adaptations in the brain and underscores the need for noribogaine.”
You would think with the millions of dollars spent on the war on drugs, said Mash, that the government or a pharmaceutical company could put noribogaine in the arsenal.
The History of Ibogaine
Dig up the roots of the four-foot tall flowering African shrub called Tabernantha iboga and peel off the bark. You will have in your hand the source of ibogaine. Teenage tribal members in the country of Gabon chewed the bark as part of an initiation rite to manhood. (Mash has called the drug a chemical bar mitzvah.)
France found a way to purify ibogaine from the bark in the early 1900s and sold it in low doses from 1939 until 1970 to help with fatigue and depression.
Ibogaine made its mark here in the early 1960s, a time when LSD was gaining popularity and was surprisingly legal. Howard Lotsof, a 19-year-old heroin addict, and 20 of his friends routinely used drugs and systematically wrote down their experiences to compare them.
In 1962, a chemist friend gave Lotsof, a film student at the time, a dose of ibogaine. Lotsof was surprised after arriving back to reality that he had lost his addiction. So naturally Lotsof gave ibogaine to seven of his friends, all of who said they emerged from the experience with no desire for drugs. Five of them stayed off heroin for six months or longer, and the two who didn’t said they wanted to remain addicts.
Lotsof didn’t do much with his discovery until 20 years later at the age of 39. He was like an exploding star, going in many different directions to gain scientific interest, funding for animal studies, and legitimacy for this drug. He formed a nonprofit corporation to promote ibogaine, inspired interest with the National Institute on Drug Abuse, and successfully filed for patents to use ibogaine to treat a variety of addictions. He also formed a company, NDA International.
He found grant money for Glick at Albany Medical College, which did the initial animal work on ibogaine and has done significant animal research since then.
In 1989, Lotsof became involved in testing ibogaine on patients in the Netherlands (the beginning of an underground of addicts helping addicts). Dr. Mash, who heard a lecture on the drug and witnessed the remarkable recoveries in the Netherlands, became the next major proponent of ibogaine. She was able to get FDA approval for a Phase 1 clinical trial here in the United States. Her trial started in August 1993 and was intended to prove safety.
“The FDA was absolutely wonderful and highly supportive and interactive. We are academic investigators studying a highly controversial substance and they were caring, responsive, and helped guide the research for ibogaine. That was my experience.”
But the bright lights on the drug dimmed suddenly after a woman died in the Netherlands’ clinical trial in 1993. She went into respiratory collapse 19 hours after taking ibogaine. A Swiss woman also died after taking ibogaine for psychotherapy in Europe around the same time.
Animal studies were also showing problems, said Frank Vocci, the ibogaine point man for the National Institute on Drug Abuse (NIDA).
Cerebral lesions showed up in rats and monkeys suffered grand mal seizures. The drug also slows the heart rate in humans, which could mean death for some people. Another troubling aspect was theunpredictability of how the ibogaine would work in the body. Ibogaine turns into noribogaine in the body, and noribogaine is the chemical that stops the cravings. But ibogaine metabolizes into noribogaine at different rates for people; it depends on the person’s metabolism. “That means it is impossible to predict the ratio of ibogaine dosage to the amount of noribogaine producd in the body,” Vocci said.
The two deaths were seen as red flags and shut down the clinical study in the Netherlands. Mash was forced to end her clinical study here in the states. The money just dried up.
Pharmaceutical companies: No interest
Really since the beginning, pharma-ceutical companies were cool to ibogaine because they didn’t see it as a moneymaker. The drug naturally occurs in nature and its molecular structure cannot be patented. Only the drug’s use to treat addictions can be patented. And because it works after just one administration, the profit motive is thought to be low. Pharmaceutical companies have been unwilling to invest in a Phase II clinical trial running from $10 million to $30 million without having sole dibs on the drug.
But what about government funding?
When a drug carries significant benefit to public health, but isn’t deemed commercially viable, the government will often help. The National Institute on Drug Abuse did have an interest in conducting clinical trials, going so far as to map out plans for Phase I/II clinical trials in 1993. But in March 1995, following the ibogaine deaths, consultants weighed in and advised against doing the studies.
Despite these problems, Mash was determined not to give up. The rats in the Johns Hopkins study showing brain damage were fed extremely high doses with only a short reprieve, which doesn’t reflect real-life treatment. And in response to the monkeys’ seizures, she said that later studies on primates did not show any toxicity. Mash acknowledged that ibogaine could kill people, especially those with bad hearts and liver problems. The Swiss woman who died was “very sick with a very sick heart” and should never have been given ibogaine. It was originally suspected that the woman in the Netherlands study may have taken heroin with the ibogaine, but blood studies show she did not. She died from an accidental overdose, Mash said.
“A vast, uncontrolled experiment”
Mash said the problems with ibogaine put her in a Catch 22. Although she’s had FDA permission to proceed with ibogaine trials since 1995, money has been a problem. In order to find the funding she needed to prove ibogaine was effective, she first had to prove it was effective. So she set up a medical facility on the Caribbean Island of St. Kitts and began working in cooperation with an addiction treatment facility based in North Miami. Hundreds of addicts were treated, and hundreds were helped, although many ultimately relapsed, she said.
“The success rate depends on if they can work a program, it depends on their motivation. If they go to a traditional treatment center without ibogaine, the failure rate is 90%. With ibogaine, it’s 40 percent to 50 percent,” Mash said.
Mash stressed that no one should ever take ibogaine except under strict medical supervision. That doesn’t always happen, however.
In the United States, there is an underground network of ex-addicts who administer ibogaine and offer training to others on how to be a caregiver. The hotspots are New York City, Chicago, Miami and Portland and the ripple effects continue from there, said Dr. Nathen Gabriel, director of operations for the Ibogaine Association.
“These addicts have received benefits and want to bring it to the world at an extremely low cost whether it’s legal or not,” Gabriel said. “For them, it’s an ethical issue of saving someone’s life.”
But what about the risk of death? In fact, Gabriel said, there is a 1 percent risk of mortality in a mainstream detox center—about the same as for ibogaine. Scientists need a rigorous trial to figure out what is causing the deaths—ibogaine or withdrawal, he said.
“Part of the problem is that we don’t have organized research. Right now, it’s guesswork,” he said.
The Ibogaine Association treats about eight patients each month, transporting them from San Diego to Playas de Tijuana, Gabriel said.
Ibogaine clinics have also been set up in Panama City, Mexico, the Caribbean, the Netherlands, and even on cruise ships. Sometimes the clinics are connected to treatment centers based in the United States, but others—like the Ibogaine Association—focus only on the administration of ibogaine (and provide contact information for post treatment).
On St. Kitts Island where Mash oversaw a clinic for several years, patients are medically screened more stringently than other clinics and constantly monitored. (Mash is no longer connected to the St. Kitts facility and now serves as a consultant for Advanced Health Transitions in Cancun).
A key question that still must be answered, he said, is whether the hallucinogenic experience is necessary for recovery, said Lotsof, who now works as a consultant on ibogaine issues.
“Ibogaine is a vast, uncontrolled experiment being conducted around the world,” Lotsof said. “What we do know is that we can take an active drug user and interrupt their chemical addiction. Nothing else can do that. In a matter of a day, we can return a person to a pre-addiction state. But for how long is a different question, but really not important. Because if you know you can interrupt your addiction, then you know you can turn around your life.”
The Future of Ibogaine
Vocci of the National Institute of Drug Abuse has not seen the human data from subjects on St. Kitts Island, but said that a peer review committee would likely consider it seriously and part of an overall argument to merit further study.
Ibogaine did provide a “chemical lead” for breaking addiction, but it was not the final answer, Vocci said.
The best route for FDA approval, he said, would be to start with a small study. He liked Mash’s approach of synthesizing noribogaine because it may react in the body more predictably in than ibogaine. He also said that NIDA would consider funding a pilot, double-blinded study as a precursor to a large-scale clinical study.
Mash said she has animal data on noribogaine for “proof of concept”—the animals stopped using alcohol and cocaine. She has also found seed money for a Phase I study, which must prove safety. The Phase II study—to prove effectiveness--will be much more challenging because the cost runs into the millions of dollars; she urges people to apply public pressure on the government for funding (in other words, call your senator and representative).
“The drug abuse problem is getting bigger and bigger and bigger. We are poisoning generations of people. It’s huge. We need pharma to join in. We need someone to step up to the plate. If it was a stupid thing, it would die, but this will outlive me. I know that with every fabric in my body.”
Although Mash was never a drug addict, her motivation for getting ibogaine approved is also rooted in the personal.
“My father battled alcoholism until the day he died at age 56. He was a tender, kind, remarkable human being. This would have helped him. …
“It really debilitates me just thinking why we can’t get a pharmaceutical company to get on board. They don’t believe they can make enough money in the addiction market. They want a multi-billion dollar drug. So what have we got? A curiosity. We’ve got an underground of people who knows it works. We have already demonstrated efficacy and safety and we know we could help millions.
Editor’s Note: For more information, visit advancedhealthtransitions.net. The Ibogaine Association also screens patients and offers treatments for $3,900 (1-877-Iboga50).
Last edited by Kuba on Mon 19 Jun, 2006 14:22; edited 1 time in total
Jovisst, noribogain ser väldigt intressant ut. Noribogain verkar vid försök på råttor ha mindre biverkningar än ibogain, trotts att ibogain omvandlas till noribogain i kroppen relativt snabbt. Därmed inte sagt att noribogain står för alla utav igobainets verkningar.
Noribogaine (12-Hydroxyibogamine): A Biologically Active Metabolite of the Antiaddictive Drug Ibogaine
M. H. BAUMANNa,d, J. P. PABLOb, S. F. ALIc, R. B. ROTHMANa and D. C. MASHb
aClinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland, USA
bDepartment of Neurology, University of Miami School of Medicine, Miami, Florida, USA
cDivision of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA
dAddress for correspondence: Michael H. Baumann, Ph.D., Clinical Psychopharmacology Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224. Tel.: (410) 550-1754;fax: (410) 550-2997.
Ibogaine (IBO) is a plant-derived alkaloid that is being evaluated as a possible medication for substance use disorders. When administered peripherally to monkeys and humans, IBO is rapidly converted to an o-demethylated metabolite, 12-hydroxyibogamine (NORIBO). We have found in rats that peak blood levels of NORIBO can exceed those of the parent compound, and NORIBO persists in the bloodstream for at least 24 h. Surprisingly few studies have examined the in vivo biological activity of NORIBO. In the present series of experiments, we compared the effects of intravenous (iv) administration of IBO and NORIBO (1 and 10 mg/kg) on unconditioned behaviors, circulating stress hormones, and extracellular levels of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens of male rats. IBO caused dose-related increases in tremors and forepaw treading, whereas NORIBO did not. Both IBO and NORIBO produced significant elevations in plasma corticosterone and prolactin, but IBO was more potent as a stimulator of corticosterone secretion. Neither drug affected extracellular DA levels in the nucleus accumbens. However, both IBO and NORIBO increased extracellular 5-HT levels, and NORIBO was more potent in this regard. The present data demonstrate that NORIBO is biologically active and undoubtedly contributes to the in vivo pharmacological profile of IBO in rats. Most importantly, NORIBO appears less likely to produce the adverse effects associated with IBO (i.e., tremors and stress-axis activation), suggesting that the metabolite may be a safer alternative for medication development.
Tydligen patenterat 2004 för: behandling av smärta och
(73) Novoneuron Inc., Miami, FL 33132, US
I patentansökninsghandlingarna framkom ett bekant namn D. Mash.
Clinical Observations of Safety after Single Oral Dose Administration
by Deborah .C. Mash; K. Allen-Ferdinand; M. Mayor; C.A. Kovera; J.F. Ayafor; I.C. Williams; F.R. Ervin
Healing Visions Institute for Addiction Recovery
Ibogaine, a naturally occurring indole alkaloid derived from the roots of Tabernanthe iboga, is currently under investigation as a therapeutic agent for drug dependence. We report here preliminary observations on the safety of single oral dose administration of ibogaine to cocaine and heroin dependent subjects. Baseline screening included a medical evaluation, physical examination, ECG, blood chemistries, and hematological work-up, as well as psychiatric and chemical dependency evaluations. Subjects (N=30) were assigned to one of three fixed-dose treatments under open label conditions: 500 mg, 600 mg, and 800 mg ibogaine. Adverse events were assessed by clinical side-effects ratings and open-ended query. No significant adverse events were seen under these study conditions. The most frequent side effects were nausea and mild tremor at early time points after drug administration. Random regression of vital signs (respiration rate, systolic and diastolic blood pressures and pulse) revealed no significant changes across time or by treatment condition. White blood count, neutrophil levels, sodium or potassium levels were in the normal range. No significant changes from baseline were seen for ALT, AST, alkaline phosphatase (ALP), and GGT. Intensive monitoring demonstrated that no electrocardiographic abnormalities were produced or exaggerated following ibogaine administration. These preliminary results demonstrate that single doses of ibogaine were well tolerated in drug-dependent subjects, and that there were no significant problems with safety. Supported in part by the Addiction Research Fund.
Articles by MASH, D. C.
Articles by MAYOR, M.
Articles citing this Article
Articles by MASH, D. C.
Articles by MAYOR, M.
Ibogaine: Complex Pharmacokinetics, Concerns for Safety, and Preliminary Efficacy Measures
DEBORAH C. MASHa,b,h, CRAIG A. KOVERAa, JOHN PABLOa, RACHEL F. TYNDALEc, FRANK D. ERVINd, IZBEN C. WILLIAMSe, EDWARD G. SINGLETONf and MANNY MAYORg
aDepartment of Neurology, University of Miami School of Medicine, Miami, Florida, USA
bDepartment of Pharmacology, University of Miami School of Medicine, Miami, Florida, USA
gDepartment of Medicine, University of Miami School of Medicine, Miami, Florida, USA
cCentre for Addiction and Mental Health, University of Toronto, Toronto, Canada
dDepartment of Psychiatry and Human Genetics, McGill University, Montreal, Canada
eHealing Visions Institute for Addiction Recovery, Ltd., St. Kitts, West Indies
fBehavior Therapy Treatment Research Center, Johns Hopkins Medical School, Baltimore, Maryland, USA
hAddress for correspondence: Deborah C. Mash, Ph.D., Department of Neurology (D4-5), 1501 N.W. 9th Avenue, Miami, Florida 33136. Tel.: (305) 243-5888; fax: (305) 243-3649.
Ibogaine is an indole alkaloid found in the roots of Tabernanthe Iboga (Apocynaceae family), a rain forest shrub that is native to western Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and thirst, and in higher doses as a sacrament in religious rituals. Members of American and European addict self-help groups have claimed that ibogaine promotes long-term drug abstinence from addictive substances, including psychostimulants and opiates. Anecdotal reports attest that a single dose of ibogaine eliminates opiate withdrawal symptoms and reduces drug craving for extended periods of time. The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. The majority of ibogaine biotransformation proceeds via CYP2D6, including the O-demethylation of ibogaine to 12-hydroxyibogamine (noribogaine). Blood concentration-time effect profiles of ibogaine and noribogaine obtained for individual subjects after single oral dose administrations demonstrate complex pharmacokinetic profiles. Ibogaine has shown preliminary efficacy for opiate detoxification and for short-term stabilization of drug-dependent persons as they prepare to enter substance abuse treatment. We report here that ibogaine significantly decreased craving for cocaine and heroin during inpatient detoxification. Self-reports of depressive symptoms were also significantly lower after ibogaine treatment and at 30 days after program discharge. Because ibogaine is cleared rapidly from the blood, the beneficial aftereffects of the drug on craving and depressed mood may be related to the effects of noribogaine on the central nervous system.
Kryphål i svensk lagstiftning? - legal status på noribogain?
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Last edited by Operator on Mon 19 Jun, 2006 16:53; edited 1 time in total
Väldigt intressant läsning. Kommer nog utvecklas mycket utefrån Ibogainets fantastiska potential i framtiden
Mycket medecinska termer i patenansökan men jag lyckades greppa det mesta. Intressant att patenansökan även innefattar administration vid smärtillstånd. Men med tanke på vilka receptorer opiater/Opioder arbetar på och där sen Ibogain/noribogain går in och normaliserar så förefaller det ganska logiskt att även diverse smärtillstånd är en bra indikation.
Noribogain kanske blir varianten som slår igenom i sverige, funderade oxå på det här med kryphål i lagarna. Sen när det är utarbetat från en väldigt seriös och helomfattande studie så är det ju ingenting man bara går in och förbjuder. Så som det vart fallet med Ibogain när det inte fanns mycket forskning kring det.
jepp, men både ibogain och noribogain har ganska korta halveringstider. Vilket leder mig till att tro att det är andra ämmne som står för huvudeffekten, ibogainet är bara nyckeln i låset s.a.s.
Kanhända är det GDNF eller BDNF som står för en del av den långsiktiga effekten ? Eller så är det en uppgradering av mottagareffekten på terminalhamnarna för GDNF som åstadkommits av ibogain?.. ja ja, många frågetecken där.
Hursomhelst kan ju ganska korta studier på patenten ge en klar fingervisning om vad som är i faggorna. Det brukar ju inte vara av pur ideélla skäl som bolagen patenterar, så något säger det alltid.
Alltfrån polymer-matrix av trunkerad GDNF placerad direkt i hjärnan till viralt producerade stamceller understödda av GDNF ... ja ja. Att säga att framtiden för många allvarliga hjärnsjukdomar inte har att göra med tillväxt av neuronalkapacitet är nog många gånger direkt fel.
Ibogaine is rapidly metabolized in the human body by cytochrome P450 2D6. Effects after ibogaine treatment lasting longer than 48 hours are therefore not likely to be caused by the initial administration of ibogaine itself. The main metabolite in humans is noribogaine (12-hydroxyibogamine) which contains a phenolic hydroxy instead of a methoxy group. Both ibogaine and noribogaine have a plasma half-life of approximately thirty minutes. It is proposed that ibogaine is deposited in fat and metabolized into noribogaine as it is released. Noribogaine throws higher plasma levels than ibogaine and may therefore be detected for longer periods of time than ibogaine. The metabolite is somewhat more active at several receptors and transporters. Noribogaine is most potent as a serotonin reuptake inhibitor and as κ and µ-opioid receptor full agonist and therefore may act as an opiate replacement similar to compounds like methadone. Noribogaine is also more potent than ibogaine in rat drug discrimination assays when tested for the subjective effects of ibogaine.
Men Mash säger att :
ibogain inte är mätbart efter 24 timmar men noribogain är det efter 30 dagar. Ja får inte alls ihop det just nu ....
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