Posted: Tue 25 Jul, 2006 08:52 Post subject: BNP en ledtråd för folklig överlevnad?
I skuggan av att det finns mortalitet tidsmässigt sambunden med ibogainbehandling står ju också ett stort intresse till att isolera faktorerna som orsaker detta.
Nivån av natriuretiska peptider av B-typ, (BNP) kan ju kanhända vara en viktig mätfaktor i en framtida preklinisk bedömning av individuell lämplighet för ibogain behandling?
1: Dimens Crit Care Nurs. 2006 July/August;25(4):149-154. Links
B-type Natriuretic Peptide Rapid Assay: A Diagnostic Test for Heart Failure.Ancheta IB.
Irma B. Ancheta, PhD(c), RN, currently teaches at the University of Phoenix for both undergraduate and graduate nursing levels. She is currently working on completing her dissertation, "Correlation of b-type natriuretic peptide levels and hospital length of stay and quality of life in congestive heart failure patients" at the University of South Florida, Tampa, Florida. The author's expertise is in the area of cardiovascular nursing, specifically in the area of heart failure.
Hospitals are constantly besieged with congestive heart failure admissions. Current studies show that the advent of the B-type natriuretic peptide (BNP) rapid assay as a quick and easy blood test is beneficial to nurses in confirming the diagnosis of heart failure. B-type natriuretic peptide is a neurohormone produced by the failing heart in response to increased volume and cardiac overload. The BNP rapid assay measures the presence of BNP levels present in the circulating bloodstream to confirm the diagnosis of congestive heart failure. It is a simple blood test that can be done at the bedside or at the clinic so it is a valid point-of-care modality. Elevated levels suggest severity of heart failure and possibility of sudden death. This article focuses on the description of the diagnostic performance of the BNP rapid assay, its clinical dimensions, and its implications to nursing practice and collaborative practice models.
PMID: 16868458 [PubMed - as supplied by publisher]
Ja varför inte? Det tål nog att fundera skarpt över att inkluderas i testbatteriet. Kanske en ren exklusionsfaktor?
1: J Cardiol. 2006 Jun;47(6):277-83. Links
[Brain natriuretic peptide and QRS duration as a predictor for cardiac events in patients with heart failure][Article in Japanese]
Taniguchi T, Kawasaki T, Miyai N, Kamitani T, Kawasaki S, Sugihara H.
Department of Cardiology, Matsushita Memorial Hospital, Osaka. firstname.lastname@example.org
OBJECTIVES: Brain natriuretic peptide (BNP) and QRS duration have been reported as independent predictors for cardiac events in patients with heart failure. The present study investigated the relationships between BNP and QRS duration to assess the prognostic value in patients with heart failure. METHODS: We prospectively examined 93 patients presenting to our emergency department with heart failure between April 2000 and April 2003 (age 69 +/- 13 years, 53 males, 40 females). BNP level and QRS duration were measured after treatment for heart failure. The efficacy end point was the composite incidence of sudden death, death for progressive heart failure, or readmission for worsening heart failure. RESULTS: During the mean follow-up period of 720 +/- 470 days, cardiac events occurred in 35 patients (sudden death in 6, death for progressive heart failure in 9, and readmission for worsening heart failure in 20). BNP level was almost equally higher in the three groups with cardiac events (mean +/- SEM; sudden death: 348 +/- 128 pg/ml, death for progressive heart failure: 390 +/- 97 pg/ml, readmission for worsening heart failure: 354 +/- 79 pg/ml) than in patients without cardiac events (213 +/- 34 pg/ml). In contrast, QRS duration was exclusively prolonged in patients with sudden death(mean +/- SEM, 125 +/- 10 msec) compared with the remaining three groups (death for progressive heart failure: 100 +/- 5 msec, readmission for worsening heart failure: 103 +/- 4 msec, no cardiac events: 108 +/- 3 msec). No relationship was found between BNP level and QRS duration in all patients with heart failure (Spearman r = 0.13, p = 0.22). CONCLUSIONS: Increased BNP level was associated with poor prognosis irrespective of mode of cardiac events, and prolonged QRS duration was related to sudden death in our cohort with heart failure. The combination of BNP level and QRS duration may have adjunctive value in predicting the prognosis in patients with heart failure.
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