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Kvinna-man, biotillgänglighet av ibogain

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PostPosted: Sat 10 Jun, 2006 11:48    Post subject: Kvinna-man, biotillgänglighet av ibogain Reply with quote

Det har tidigare diskuterats att kvinnor skulle ges en lägre dosering än män pga av högre biotillgänglighet hos kvinnan.

VIlket verkar ha lett till att en del rekomendationer markerar att kvinnor ska administreras mindre dos/kg.

Nedan om biotillgängligheten för ibogain på hon/han könade råttor.
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Pharmacology Biochemistry and Behavior
Volume 57, Issue 4 , August 1997, Pages 809-815


doi:10.1016/S0091-3057(96)00383-8
Copyright © 1997 Elsevier Science Inc. All rights reserved
Articles
Sex Differences in Ibogaine Antagonism of Morphine-induced Locomotor Activity and in Ibogaine Brain Levels and Metabolism

S. M. Pearlb, L. B. Hougha, D. L. Boyda and S. D. Glicka, *

a Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY 12208 USA
b Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260 USA

Received 18 April 1996; accepted 30 July 1996. Available online 7 November 1997.


Abstract
The present study demonstrates that the putative antiaddictive agent ibogaine produces more robust behavioral effects in female than in male rats and that these behavioral differences correlate with higher levels of ibogaine in the brain and plasma of female rats. There were no differences in basal locomotor activity between the sexes, and the response of rats to ibogaine differed between the sexes even in the absence of morphine. Five h after receiving ibogaine (40 mg/kg, IP), antagonism of morphine-induced locomotor activity was evident in female but not in male rats. Either 19 h after administration of ibogaine (10–60 mg/kg, IP), or one h after administration of noribogaine (5–40 mg/kg, IP), a suspected metabolite, antagonism of morphine was significantly greater in female than in male rats. Brain and plasma levels of ibogaine (1 h) and noribogaine (5 h), measured by gas chromatography-mass spectrometry, were greater in females as compared with males receiving the same dose of ibogaine. Levels of both ibogaine and noribogaine were substantially lower at 19 h than at earlier times after ibogaine administration, contrary to a previous study in humans. For both sexes, subcutaneous administration of ibogaine (40 mg/kg, IP, 19 h) produced greater antagonism of morphine-induced locomotor activity than did a comparable intraperitoneal injection, consistent with previous studies from this laboratory demonstrating that the former route of administration produces higher levels of ibogaine in the brain. These data show that there are sex differences in the effects of ibogaine and that this may be due to decreased bioavailability of ibogaine in males as compared to females.

Author Keywords: Ibogaine; Noribogaine; Morphine; Locomotor activity; Sex differences; Route of administration

Index Terms: locomotion; ibogaine; morphine


*Dr. Stanley Glick, Department of Pharmacology & Neuroscience, Albany Medical College, A136, 47 New Scotland Ave., Albany, NY 12208, Phone: (518)262-5303, Fax: (518) 262-5799, Email: SGlick@ccgateway.amc.edu
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